CONTENTS

The composite films of dendron-appended porphyrin (den-por) and C₆₀ (den-C₆₀) were prepared as a promising candidate for the photovoltaic applications. The composite films were subjected to absorption and photoluminescence spectros copic measurements. We determined that solid-state film, comprised of 1:0.5 ratio of den-por/den-C₆₀, showed an efficient photoluminescence quenching via donor-to-acceptor electron transfer.

In this study, we investigated the alternating multilayer depositions using cationic polymer PDDAC and anionic porphyrin dye MTCP on the glass plate. Using a self-assembly layer-bylayer technique, the multilayer films consisting of PDDAC and MTCP have been successfully prepared by electrostatic attraction forces. The growth of multilayer fabrications was examined by UV-vis spectrophotometer and Atomic Force Microscopy (AFM) analysis. The absorption spectra of the deposition multilayers represented gradual increasing characteristic of bilayer numbers. The AFM images revealed that the multilayer fabrications were progressive and relatively uniform.

Copper phthalocyanine tetrasulfonate has been used to sensitize nanocrystalline TiO₂ that prepared by a sol-gel method using sodium polymethacrylate. The photo-degradation of the hybrid type photosensitizer was measured using A07 as an indicator at He-Ne laser with wavelength of 633 nm.

A series of dendritic multi-porphyrin array systems were prepared as mimics of natural light harvesting antenna complexes to study the excitation energy transfer from peripheral P_Zn units to the focal core P_FB. The large number of chromophore units in the dendrimers allowed for the efficient capture of visible photons and resulted in highly efficient photoexcited energy transfer.

We synthesized 2,3-dicyanopyrazine and metallophthalocyanines with different central metals (Ni, Mg, Cu) containing (±)camphorquinone substituent. Their spectral properties were discussed in relation to their chemical structures. The synthesized tetrapyrazino porphyrazines were characterized by UV-visible spectroscopy, MALDI-TOF-MS (matrix-assisted laser desorption ionization timeof-flight mass) spectroscopy and 1H NMR spectroscopy.

We have designed and synthesized novel Zn(II)-porphyrin derivati ves. They incorporated the electron donating group of a pendant triphenylamine into cyano-substituted or non-substituted stilbene moiety in the 5,10,15-meso position and carboxylic acid group in the 20-meso position in a porphyrin derivative. These Zn(II)-porphyrin derivatives have been used to fabricate dye-sensitized solar cells based I-/I2 liquid electrolytes as dye sensitizers and their device performances were evaluated by comparing with that of a standard Ru(II) complex dye.

The tin(IV) porphyrin complex with chiral amino acid ligands trans-bis(L-prolinato)[5,10,15,20-tetrakis(4-pyridyl) porphyrinato]tin(IV) (1) was synthesized and fully characterized. The X-ray crystal structural analysis of 1 reveals that the Sn(IV) center is octahedrally coordinated by the porphyrin occupying the square base and axial coordination of two L-prolinate ligands in trans-position with respect to each other. The pyrrolidine rings of the L-prolinate ligands in 1 exhibit a C_s-C_β-exo envelope conformation with C_s symmetry. The non-classical hydrogen bonding interactions mainly contribute to assemble 1 into one-dimensional packed structure.

We investigated regulation of intracellular Ca²⁺ induced by photodynamic therapy with a new chlorin-based photosensitizer, DH-II-24, in human gastric adenocarcinoma cells. DH-II-24-mediated photodynamic therapy produces intracellular ROS via elevation in intracellular Ca²⁺, contributed, at least in part, by mitochondria, which results in necrotic death of the gastric adenocarcinoma cells.

Two new imidazole substituted chlorin derivatives, namely (4-[1-imidazolyl]-phenyl)-amide pyropheophorbide-a (IPA) and (3-[1-imidazolyl]-propyl)-amide pyropheophorbide-a (IPP) have been synthesized. Their cell viabilities on A549 human lung adenocarcinoma cells were investigated. The result shed a light on the possibility to design an effective photosensitizing agent with high phototoxicity as well as low dark toxicity by incorporating imidazole substituents into the macrocycle of chlorin.

By linking paramagnetic gadolinium [Gd(III)] ion to tumor selective chlorin-based photosensitizers in PDT, cancer cell can be easily detected with high sensitivity and cured by appropriate laser irradiation simultaneously. The present study described the synthesis of monomer and dimer chlorin derivatives, such as pyropheophorbide-a and purpurin systems, conjugated with Gd(III) diethylenetriaminepentaacetic acid (DTPA) via DTPA dianhydride for the evaluation as contrast agents for MRI.

Due to bacterial resistance, there has been increased interest in developing photodynamic therapy for local infections. A requisite for an effective antimicrobial treatment for superfi cial wound infections is its effectiveness in the inevitable presence of wound fl uid. The use of PDI in order to treat the skin/burn wound infections may represent a useful alternative to conventional antimicrobial treatments and thereby may help to reduce the emergence of antibiotic resistance.

In this study we applied phototreatment to cancer cells with 2 J.cm^-2 of red light after sensitizing with 9-hydroxypheophorbide-α (9-HpbD-α), a new chlorophyll-derived photosensitizer. We conclude that genistein sensitizes CaSki cells to apoptosis treated with PDT by 9-HpbD-α (0.59 ¦Ìg/mL) through mechanisms that involve downregulation of the E6*I, E6*II, and E7 oncogenes, activation of caspase-8 or caspase-3, and ER stress.

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